In silico studies revealed a crucial role for miR-146a on progression of Helicobacter pylori induced gastric cancer

Stomach cancer is currently ranked as the fourth most common cancer and the second regarding to the mortality rate. Environmental and genetic factors both play crucial role in the onset of inflammation in the stomach and progression of the cancer. In a majority of gastric cancer cases, Helicobacter Pylori infection is a responsible factor. Nowadays, the micro RNAs are pinpointed as the powerful molecules in the field of disease genetics. In the present study by implementing several bioinformatics database, we have undertaken a research on the association of miR-146a with the expression of the genes involved in cell signaling pathways in gastric cancer development.
This type of study was theoretical bioinformatics. The first step to candidate the most important miRNAs is to collect data from the previous studies; then, miRWalk 2.0 and miRTarBase databases were chosen for primary studies. The final review was made at David database in order to achieve pathways involved in gastric cancer.
Based on the results from this study, miR-146a was predicated as a key factor in preventing the cancer progression by affecting an increase on metastasis and tissue attack and preventing apoptotic pathways.
Data revealed that the expression of miR-146a increased the progress of gastric cancer. Thus, the analysis of the miR-146a expression could be accounted as a valuable marker for prognosis of gastric cancer.