Evaluation of nerve regeneration of Commiphora myrrha extract on experimental sciatic nerve injury in rabbit

Peripheral nerves are structures frequently affected by traumatic lesions. Neural tissue is one of the most important tissues of the body which recovers extremely sluggishly after being injure. The resin of Commiphora myrrha (Burseraceae) has been used for several centuries for the treatment of various diseases in the traditional medicines of India, China, Rome, Greece and Babylon. They are used in indigenous medicines for the treatment of wound, pain, arthritis, fractures, obesity, parasitic infection and gastrointestinal diseases. In this study, 30 New Zealand 35-36 weeks old and weighing 2.5-3 kg male rabbits were used, and randomly divided into four groups (A, B, C, D, E and F) of 5 rabbits each, according to the procedure performed. Group A (control), group B (userin), group C (commiphora 2.5%), group D (commiphora 5%), group E (commiphora 10%), group F (commiphora 20%). The animal was anesthetized and in all groups the nerve was sharply cut, and then anastomosed with nonabsorbable 6/0 material suture. For evaluation reoair healing, 45 days after surgery, nerve samples were sent to laboratory. In this study some parameters such as bleeding, inflammation, hyperemia, and fibroplasia were evaluated. There is significant difference between groups C and D with others groups. The results show commiphora has positive effect on sciatic nerve regeneration in rabbits.