Total phenol and flavonoid contents of Meristotropis xanthioides Vassilcz. species extract and its protective effect on ethanol-induced hepatotoxicity
Author(s):
Abstract:
Aim: The aim of this study was to assess the protective effect of Meristotropis xanthioides extract on ethanol-induced hepatotoxicity.
Material and
Material and
Methods
The total phenol and flavonoid contents of the species were measured by Folin Ciocalteu and AlCl3, respectively. Male Wistar rats were divided into three groups: group 1 (control), group 2: received 1ml 50 % ethanol, group 3 : received 1ml ethanol (50 %) plus the extract (500 mg/kg), each group consisted of six rats. All treatments were performed by intragastric administration. Silymarin was used as positive control. Biochemical, histological and morphological analyses were used for evaluation of hepatotoxicity.Results
The extract had high total phenolic and flavonoid contents. Alcohol consumption significantly increased liver/body weight ratio, amounts of tissues malondialdehyde (MDA), H2O2 and also liver enzymes in blood in comparison to other groups. Histological examination showed that alcohol consumption injures liver tissue intensely. All these alcohol-induced changes were effectively inhibited by treatment with the extract.Conclusion
This research confirmed that the species can represent the protective role on ethanol-induced hepatotoxicity and suggested its capacity to apply as a new healthcare food and drug supplement.Keywords:
Language:
Persian
Published:
Journal of Cell &Tissue, Volume:7 Issue: 3, 2017
Pages:
323 to 332
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