The effect of feeding with Prosopis farcta aqueous extract in reduction of hyperlipidemia risk and liver enzymes level in hypercholesterolemic rats

Recent studies show that medical vegetables such as Prosopis farcta have substances with antioxidant effect which decrease serum lipoprotein in animals fed with hyperlipidemic diet. The main purpose of this study was to investigate the effect of Prosopis farcta extract on serum lipid and liver enzymes in hyper-cholestrolemic rats. In this study, 20 vistar male rats with approximately 300-350 g-weight and 10-week age were taken from infertility center of Yazd. At first, the rats were fed with a base diet containing protein, fiber and fat for two weeks. Then they were randomly divided into four groups of five animals: Group 1, standard diet, Group 2, a diet containing cholesterol, Group 3, a diet containing standard diet with Prosopis extract and group 4, a cholestrolemic diet with Prosopis extract. All animals were fed for 13 weeks. Total cholestrole (TC), triglyceride (TG), Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), low density lipoprotein and high density lipoprotein were measured before the experiment, and 30 days and 90 days after feeding. The data were analyzed using one way Anova. The p-values below 0.05 (p