Effects of Walnut Leaf Hydro-Alcoholic Extract by Forced Swimming Stress on Serum Levels of Glucose, Insulin and Liver Parameters in Adult Male Rat's Diabetic

Diabetes is a metabolic disorder which is associated with secretion reduction or insulin resistance. Since different stress causes play a crucial role in incidence and chemical drugs side-effects of this disease, this study is aimed to investigate the effects of walnut leaves on insulin, glucose, albumin, AST ALT and ALP enzymes in diabetic and diabetic by forced swimming stress.
In this experimental study, 50 adult male rats divided into 5 groups: control, diabetic, diabetic treated with walnut leaves (200mg/kg), diabetic with swimming stress in water 15°C and diabetic treated with swimming stress and walnut leaves. At the end of 21 days injection and phlebotomizing, serum levels of insulin, glucose, albumin and ALT, AST and ALP enzymes have been measured and the related data by using SPSS-18 software, ANOVA and Tukey has been analyzed.
FINDINGS: The results showed that diabetic and diabetic with swimming caused a significant reduction of insulin (4.46±.26,5.06±.14)(P The results showed swimming and diabetic causes insulin to be reduced. As a result, glucose and ALP, ALT and AST enzymes have been increased and blood albumin has been decreased. Also, it is observed that walnut leaf extract causes the above mentioned indices to be modified