Protective Effects of Ethanolic Extract of Allium Saralicum R.M. Fritsch on CCl4- Induced Hepatotoxicity in Mice
Abstract:
Background And Objective
Due to their anti-oxidant and anti-inflammatory compounds, medicinal plants can protect the liver against hepatotoxicant induced injuries. The aim of this study was to evaluate the protective effects of Allium Saralicum R.M. Fritsch (ASRMF) on CCl4- induced hepatotoxicity in mice.
Materials And Methods
In the present experimental study, 35 male mice were divided into 5 equal groups. The negative control received 1ml/kg of olive oil and positive controls received 1 ml/kg of 50%-50% solution of olive oil and CCl4, intraperitoneally. Three treatment groups received 200, 800, and 1600 µg/kg of ethanolic extract of ASRMF in addition to CCl4 through gavage. All administrations were done twice a week for 45 days. On the last day, serum levels of samples of ALT (Alanine aminotransferase), AST (Aspartate aminotransferase), and ALP (Alkaline-phosphatase) enzymes were measured. Total volume of the liver, hepatocytes, sinusoids, portal veins, central veins, hepatic arteries, and bile ducts were estimated in histological sections. The data were analyzed using one-way ANOVA and post-hoc Tukeys’ tests.
Results
As compared to the CCl4 - treated group, ethanolic extract of ASRMF could significantly decrease the rised levels of liver and also volume of the liver, hepatocytes, and sinusoids (P
Conclusion
It seems that ethanolic extract of ASRMF at low and intermediate doses can protect the liver against hepatotoxicants induced injuries.
Language:
Persian
Published:
Journal of Rafsanjan University Of Medical Sciences, Volume:16 Issue: 3, 2017
Pages:
227 to 238
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