Teratogenic Effects of Intravitreal Injection of Bevacizumab in a Pregnant Rat Model

Title: Teratogenic Effects of Intravitreal Injection of Bevacizumab in Pregnant Rat Models
Aim: To investigate teratogenic effect of intravitreal injection of bevacizumab in pregnant rat model
Twenty seven female Wistar rat were inseminated. Pregnant rats were divided into 6 groups (three groups as case and three as control groups). Each case and control groups divided according to the day of intravitreal injections (day 2, 10 and 18). Rats in the case groups received 4 µl intravitreal injection of bevacizumab and the control groups received same volume of distilled water.
The tail and umbilical cord length in case groups 1, 2 and 3 did not display any significant differences compared with their control groups. The fetal weight was significantly lower in the case groups 1 (p Intravitreal bevacizumab has developmental effect when administered in the early stages of pregnancy; but it is safe when administered in the last week of pregnancy in rats.