Chronic Exposure of Female Rats with Morphine before the Gestation Causes Reduction of Spatial Memory and Increase of Vulnerability to Opiate Intake in Next Generation Offspring
Abstract:
Background and Objectives
According to the increasing opioids abuse between women and pathophysiological effects of chronic exposure of opioids on mothers which might indirectly affect their offspring, herein, consequences of chronic morphine consumption and its withdrawal before the gestation was investigated on spatial memory, avoidance memory and vulnerability to morphine intake in offspring of first generation.
Materials and Methods
Twelve female Wistar rats were randomly divided into two groups. Morphine mothers group received morphine solution (0.4 mg/ml) for two months. Control mothers group received tab water. One month after stopping morphine consumption, mating was occurred. After the parturition, offspring was divided in separated male and female groups and was used as the target groups of the study. Spatial memory through Water Maze, avoidance memory through Shuttle Box and vulnerability to morphine intake through voluntary consumption of morphine solution were investigated.
Results
Mean of morphine solution consumption in male and female offspring of morphine mothers was significantly higher in compare to male and female offspring of control mothers (P
Conclusion
Our study revealedchronic morphine consumption before the gestation causesdamage of spatial memory in male offspring and also increases vulnerability to opiate intake of male and female offspring.
Language:
Persian
Published:
Journal of Sabzevar University of Medical Sciences, Volume:24 Issue: 1, 2017
Pages:
17 to 27
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