Protective Effect of Royal Jelly and Vitamin C Against Phenylhydrazine-Induced Nephropathy in Mice: Histological Study

Aim: The aim of the present study was to investigate the effects of royal jelly (RJ) and vitamin C (vit C) against PHZ-induced nephropathy in mice.
Material and Adult male mice were randomly divided into eight eight-membered groups. The PHZ was administered to four groups of mice at a dose of 60 mg/kg per 48 hours intraperitoneally for 35 days. Three of these groups received vit C (250 mg/kg per day) intraperitoneally, RJ (100 mg/kg per day) orally and vit C with same doses, four hours before PHZ administration, respectively. A vehicle-treated control group and vit C, RJ and vit C control groups were also included. Serum and renal tissue samples were collected 24 hours after the last treatment and subjected to biochemical and histological examinations, respectively. The data were analyzed by one-way analysis of variance followed by Duncan test for post hoc comparisons.
The PHZ treatment caused a significant (P The Vit C and RJ can minimize PHZ-induced nephropathy in mouse through oxidative reactions inhibition.