Effect of Gallic Acid and Endurance Exercise Training on BDNF in a Model of Hippocampal Degeneration

The aim of this study was to investigate the effect of gallic acid on hippocampal level of brain derivative neurotrophic factor (BDNF) in trimethyltin chloride (TMT)- intoxication rats after eight weeks of endurance training.
Seventy Sprague-dawley male rats were selected and randomly divided into seven groups, including: (1) Control, (2) Sham, (3) Gallic acid 50, (4) Gallic acid 100, (5) Endurance training (4), (6) Training Gallic acid 50, and (7) Training Gallic acid 100. Hippocampal degeneration was induced by TMT (8 mg/kg) in all groups except control animals. During eight weeks, rats of groups 3, 6 and 7 ran on treadmill’s without incline at a speed of 15 to 20 meters per minute for 15 to 30 minutes per session, five times weekly. In addition, groups 4 and 6 were treated with gallic acid (50 mg/kg) and groups 5 and 7 with gallic acid (100 mg/kg) every day for 14 days.
The findings showed that hippocampal levels of BDNF in all test groups was significantly higher than sham group.
Endurance training and gallic acid as well as the combination of them increase the level of hippocampal BDNF in a model of TMT-intoxication.