Circulating levels of omentin-1 in patients with breast cancer

It seems adipocytokines play an important role in breast cancer. Omentin-1 is a novel discovered plasma adipocytokine produced mainly in visceral adipose tissue. The aim of present study was to estimate. Circulating levels of omentin-1 in postmenopausal breast cancer patients as compare to healthy postmenopausal subjects.
This study consisted of 30 postmenopausal women with newly diagnosed breast cancer and 30 healthy postmenopausal subjects aged 45 to 70 years. Serum levels of omentin-1 were measured by enzyme-linked immunosorbent assay.
The mean age of the case group was 54.3±8.3 years, and the control group was 50.3±3.2 years. The mean serum levels of omentin-1 in the case group were 73.1±29.7 ng/mL and in the control group were 108.8±65.4 ng/mL. The mean serum omentin-1 levels were found to be significantly lower in breast cancer patients (P=0.009). We also demonstrated the negative correlation of Omentin-1 with BMI in both groups (p=0.005), however, we did not find any association between age and serum omentin-1 levels (P=NS).
Our studied showed that Omentin-1 level was significantly reduced in the breast cancer patients as compare to healthy controls. Decreased omentin-1 levels may contribute to the development of cancer, however determination of its role and mechanisms needs more investigations. To sum up, our data suggest that omentin-1 can be used as a marker for early detection of breast cancer in postmenopausal women.