ACUTE AND CHRONIC EFFECT OF UPPER AND LOWER BODY AEROBIC INTERVAL TRAINING ON TNFA AND LEPTIN IN WOMEN WITH MULTIPLE SCLEROSIS

Evidence has indicated the beneficial impact of exercise training on physical performance and quality of life in individuals with multiple sclerosis (MS). In addition, it seems that MS associates with immune system dysfunction and chronic inflammation, but the cytokine response and adaptation to exercise are not completely investigated. Therefore, the current study was designed to investigate the acute and chronic effect of upper and lower body interval training on tumor necrosis factor (TNFα) and leptin concentration in women with MS.
Ten women with MS and ten healthy matched women participated in the study to perform single-bout aerobic interval exercise (acute design). Blood samples were drawn before, immediately, and 1-hour after completion of the exercise to determine serum levels of TNFα, and leptin. Furthermore, twenty women with MS were randomized into two control and training groups. The control group received no intervention and the training group performed 8 weeks of upper and lower limb aerobic interval training (chronic design). Before and after training period, the blood samples were collected to determine serum levels of TNFα, and leptin.
Levels of TNFα responded to the exercises was similar in control and MS subjects (p>0.05). For leptin, both groups indicated a significant trend to decrease 1-hour after exercise (p These findings suggested that aerobic interval training can be a strategy to modulate immune system at least through impacting inflammatory cytokines levels successfully. Additionally, it seems that exercise is not more influential in inflammatory acute response of cytokines in individuals with MS than in healthy people.