The effects of 8 weeks high intensity interval training on serum levels of TNF-α and insulin resistance index in obese men with type-2 diabetes

TNF-α is one of the Proinflammatory Cytokines mainly seen in Adipose tissue, Lymphocytes and Fibroblasts which increases in obese men and this increment is associated with insulin resistance and lots of metabolic diseases such as diabetes. The following research aimed to investigate the effect of HIIT exercises on changes of TNF-α and insulin resistance index.
This experimentation included 24 obese men with type-2 diabetes who were randomly divided into two groups of Control and HIIT (n=12). The HIIT group performed regular exercises for 8 weeks long (3 sessions in every other days of a week= 30 training sessions in all). The assumptions of homogeneity of the slope of the regression line and also the linearity of the relationship between the scores before and after the practice is used and after the confirmation, Covariance analysis test is used (p HIIT training has a significant impact on TNF-α (p= It is concluded that HIIT trainings per 8 weeks has been able to reduce the plasma concentrations of TNF-α and insulin resistance index in obese men with type-2 diabetes. HIIT trainings have possibly restrained TNF-α by reducing the production of IL-6 and TNF-α itself has restrained the activity of insulin and some of its poor effectors too.