Mouse skin wound Healing using Lucilia sericata maggot extract

Wounds are one of the clinical problems and can be seen in the form of acute or chronic, due to its importance wound care management and medical treatment is a priority. Now a day new look to traditional medicine and biological products as opposed to synthetic drugs has emerged in this case.
In this study the effect of Lucilia sericata maggot extract on wound healing were studied, for the purpose the extract was evaluated by MTT assay to assess its in vitro effect on cell growth and its effect on cell migration and in vivo effects in created mouse skin wound healing were also evaluated.
The study shown that IC50 was not detected for 24 hours but for 48 and 72 hours were 28.7 and 23.45 microgram per milliliter respectively. Results showed that best healing can take place during first 24 hours using 12.5 microgram per milliliter, resulting in the induction of cell proliferation and cell migration but during 48 hours this effect get decreased and in 72 hours resulted to cell growth inhibition.
And the results of animal modeling also showed that the 12.5 microgram per milliliter extract promotes mice wound healing.
According to the results and the positive effect of the extract within 24 hours on skin wound healing and also cell growth and because of some physical as well as psychotherapists hardness in live larva administration on the wounds of patients, it is suggested study get expand and experimental level then be studied on human wounds.