The Effect of Salvia shariffi and Salvia virgata Hydroalcoholic Extracts on Some Serum Biochemical Parameters in Male Hyperlipidemic Rats

Hyperlipidemia is a progressive worldwide metabolic disorder. The aim of the present study was evaluation of effects of Salvia shariffi and Salvia virgata hydroalcoholic extracts on some serum biochemical parameters in hyperlipidemic male rats.
In this experimental study, 40 male Wistar rats were randomly divided into 4 equal groups including control, hyperlipidemic rats, and hyperlipidemic rats treated with S. virgata and S. shariffi hydroalcoholic extracts (200 mg/kg bw). High-fat diet was administered to rats for one month. Then, hyperlipidemia was confirmed by measurement of serum triglyceride and cholesterol levels and the extracts were orally treated to the groups for 21 days. Finally, serum cholesterol and triglyceride levels and hepatic enzymes were measured and the obtained data were analyzed using one-way ANOVA and Tukey's post hoc test.
Comparing to the hyperlipidemic group, the serum levels of cholesterol, triglyceride, and low-density lipoprotein were significantly reduced in the treated groups but this reduction was brilliant in the group treated with S. shariffi (P Both extracts could improve lipid profile and liver enzymes in hyperlipidemic rats but this improvement was more pronounced in the S. shariffi treated group.