Evaluation of amprolium and toltrazuril efficacy in controlling natural intestinal rabbit coccidiosis

This trial was undertaken with the objective to evaluate the efficacy of amprolium, toltrazuril and their combination in rabbits naturally infected with Eimeria species (32 × 103 ± 4.63 oocysts per gram (OPG) of faeces). Thirty-six rabbits (11 weeks old with average body weight (BW) 2000 ± 75 g), were randomly allocated into six groups (six kits each), namely, negative untreated and was retained as negative control (group 1), infected and kept untreated (group 2), treated with single oral dose of amprolium at 50 mg/kg BW for 5 days (group 3), received toltrazuril at 5 mg/kg BW for 2 days (group 4), treated orally with toltrazuril at 2.5 mg/kg BW, two doses with 5 day interval (group 5) and given oral doses of both amprolium and toltrazuril at 50 mg and 5 mg/kg BW (group 6), respectively. Clinical signs, mortalities, production data (feed consumption, feed conversion rate, BW, body weight gain (BWG), and performance index (PI)), OPG of faeces and the percentage of OPG reduction were recorded. The results indicated that both toltrazuril, amprolium and their concurrent use significantly (P