Association between SOD1 Polymorphism(+35A/C) and Senile Cataract
Message:
Abstract:
Introduction
Senile cataract is the most prevalent cause of blindness in the world. Variety of causes are involved in the pathogenesis of senile cataract, the most important reason is oxidative stress. Oxidative stress occurs because of increased production of free radicals in the body and decrease antioxidant capacity. One of the defense systems against free radicals is superoxide dismutase I (Cu/zn SOD). SOD enzyme catalyses the dismutation of superoxide anion to O2 and H2O2. Several polymorphisms have been found associated with SOD1 gene. Present study has been done to evaluation effects of genetic polymorphism, including SOD1�>C polymorphism in senile cataract patients and normal individuals.
Materials And Methods
in this case – control study, there are 120 patients with senile cataract and 104 healthy people. We collected 2ml of whole blood in tubes containing EDTA, and then DNA extraction was performed. Polymorphisms were detected by PCR–RFLP technique.
Results
The distribution of AA, AC genotypes of SOD1 gene in the patient with senile cataract were 99.2% and 0.8%. Similarly, distribution of AA, AC genotype in the healthy group were 99% and 1%, respectively. The genotype of CC was not seen in none of the patients and control subjects.
Conclusion
No significant differences in the distribution SOD1�>C polymorphism was observed between cases and controls.
Language:
Persian
Published:
Alborz University Medical Journal, Volume:6 Issue: 3, 2017
Pages:
219 to 226
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