Effect of Abilizol Drug on Functional Test (LFT) and Liver Tissue Changes in Adult Male Rats

The liver has important role in the metabolism of chemical drugs and plasma protein synthesis. Abilizol is used in the treatment of schizophrenia and bipolar maniac disorders. In this study the effect of abilizol have been observed on serum levels of liver enzymes, total protein, albumin and liver tissue changes.
In this experimental study 50 adult male rats from wistar race were divided in to 5 groups of 10.The experimental groups which received 5, 10 and 15 mg/kg of abilizol drug orally for 28 days. The control group which received nothings and the sham group which received solvent. At the end of this Period, blood samples were taken from all groups. ALT (Alanine Transaminase), AST (Aspartate Transaminase), ALP (Alkaline phosphatase), total protein and albumin were measured. Also histological changes of liver studied.
No significant differences were observed in levels of ALT , ALP and albumin enzymes between experimental and control groups. In experimental group received 15mg/kg abilizol drug showed a significant decrease in level of AST in compared with control group. In experimental group received 15mg/kg abilizol drug showed a significant decrease in level of total protein in compared with control group (p≤0.05). Density of liver tissue in all experimental groups received abilizol drug decrease significantly in compared with control group.
Results show that abilizol is a cause of liver parenchymal cell failure and decreases liver enzymes levels.