Iron Ore Pellet: A Natural and Reusable Catalyst for Synthesis of Dihydropyrimidine Derivatives in Aqueous Media

Notice to importance and application of dihydropyrimidine heterocycles as diverse biological and pharmaceutical compounds in chemistry and biochemistry, in this project, an efficient synthesis of 3, 4-dihydropyrimidin-2 (1H) - ones (DHPM) derivatives is achieved from an one-pot tree component reaction of aromatic aldehydes, ethyl acetoacetate and urea in the presence of iron ore pellet as natural and reusable catalyst in H2O / EtOH solution. This methodology offered several advantages such as good yields, cheap natural and reusable catalyst, simple procedure and simple purification steps. The use of water as the reaction medium makes the process environmentally and eco-friendly benign.