Therapeutic effect of the thiamine on the histomorphometric structure of testis following lead poisoning in mouse model

Several studies have been reported the effects of thiamine on the testis tissue caused by lead poisoning, but the effect on morphometric structure of testis in mice that have received the Lead has not been studied. The aim of this study was to evaluate the effect of thiamine on the morphological structure of the seminiferous tubules were contaminated with lead. This experimental study was performed on 40 Wistar rats. The mice were randomly divided into 4 groups of 10 specimens, including groups A (control), B (thiamine recipient), C (a stump flock Pb) and D (treated with thiamine and Pb), respectively. Lead to a value of 8.5 mg per liter and thiamine supplementation at a rate of 30 mg per liter was administered orally every day. Routine histological tissue specimens prepared and using one-way ANOVA was used to analyze the data. The lead induction causes morphological disorganization in the seminiferous tubules including the cell lines when compared to groups A and B and thiamine supplementation partially reduced these changes. Seminiferous tubules diameter and thickness of the epithelium layer genital germ tubules in the lead group decreased significantly when compared to the control group (P