The Effect of Ferulic Acid on Cognitive Disorder And Brain Structural Deficit in Mice in Cuprizone Induced Animal Model of Multiple Sclerosis
Abstract:
Background And Objective
Ferulic acid is a polyphenolic compound derived from some fruit and different cereals. Previous studies have shown that this compound has antioxidant, anti-apoptosis, and differentiation properties in the nervous system. The aim of this study was to evaluate the effect of ferulic acid on the death of oligodendrocytes and demyelination in male C57B6 / J mice in cuprizone induced animal model of multiple sclerosis.
Material and
Methods
In this study, demyelination was induced by oral administration of rats with the 0.2% cuprizone that was added to the usual diet during 6 weeks. Animals were fed daily with ferulic acid at doses of 10or 100 mg / kg of body weight. At the end of the sixth week, the passive avoidance and Y maze test were performed. Then, animal brains were removed and fixed to histological studies using Luxol–Fast-Blue staining
Results
The results of this study showed that ferulic acid reduced the random entry of animals into the arms of the Y maze in compared to the cuprizone treated group [p
Conclusion
The results of this study showed that ferulic acid plays a neuroprotective role in cuprizone models of multiple sclerosis through reducing neuronal demyelination and oligodendrocytes death.
Language:
Persian
Published:
Journal of Rafsanjan University Of Medical Sciences, Volume:16 Issue: 6, 2017
Pages:
541 to 552
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