Efficacy of Granisetron on Attenuation of Hemodynamic Responses of Parturients Undergoing Elective Cesarean Delivery under Spinal Anesthesia

Maternal bradycardia and hypotension are the most common intraoperative complications after spinal anesthesia during cesarean delivery. Prophylactic administration of ondansetron has been reported to provide a protective effect. In this study we evaluated the effect of intravenous granisetron, another serotonin 5-HT3 receptor antagonist, on prevention of these complications.
Thirty-four ASA class I-II patients undergoing elective cesarean section under spinal anesthesia were randomly allocated into two equal groups, control saline (n=17) or granisetron groups (n=17). After insertion of standard monitorings,5ml/kg lactated Ringer’s solution was infused over 15 minutes. In saline group 3ml of 0.9% saline and in granisetrone 3mg (3ml) granisetron was injected intravenously five minutes before spinal anesthesia. Systolic and diastolic blood pressure and heart rate were all recorded every two minutes during first twenty minutes and then every five minutes until the end of surgery and compared between the groups.
Demographic data and median of sensory block level were not statistically different between the groups. There was no statistical difference between the study groups regarding the systolic, diastolic and heart rate at measured points except at second minutes after spinal anesthesia that was lower in saline group (P=0.01).
This study showed that intravenous granisetron has little protective effect on attenuation of hemodynamic responses of parturients undergoing elective cesarean section under spinal anesthesia.