The effect of lovastatin on cognition impairment induced by bilateral electrical lesion of nucleus basalis magnocellularis in the Alzheimer's disease model in adult male rats
BackgroundStatins, inhibitors of 3-hydroxy-3-methyl glutaryl coenzyme A reductase, are widely used as medication to lower cholesterol levels in human patients. Much evidence indicates that statins can also exert neuroprotective actions. So, this study aimed at examining the effect of lovastatin on cognition deficit induced by bilateral electrical lesion of nucleus basalis magnocellularis (NBM) in the Alzheimers disease model in adult male rats.
Materials And MethodsIn this experimental study, 56 adult male wistar rats were divided into 8 groups (n=7): control (intact), NBM lesion group (which received electrically- induced lesion 0.5 mA in 3s), sham group (the electrode was impaled into the NBM with no lesion(, lovastatin groups (lesion, 5, 10, 20 mg/kg) and DMSO 5% group (NBM lesion ೄ 5%). Acquisition and retention testing was done by using an eight-radial arm maze in which the patterns of arm entries were recorded for calculating working memory errors, reference memory error and latency in each group.
ResultsThe bilateral NBM lesion resulted in significant reduction of spatial memory in acquisition and retention tests in the form of increased working and reference memory errors compared to the control group (P
ConclusionThe electrical NBM lesion can reduce spatial memory function and the lovastatin therapy after brain injury improved cognitive disorders. It seems that lovastatin by reducing the activity of the acetylcholinesterase enzyme and increasing acetylcholine transferase enzyme activity can cause improvement in learning and memory capability.
Feyz, Volume:21 Issue:5, 2017
422 - 432
روشهای دسترسی به متن این مطلب
در سایت عضو شوید و هزینه اشتراک یکساله سایت به مبلغ 300,000ريال را پرداخت کنید. همزمان با برقراری دوره اشتراک بسته دانلود 100 مطلب نیز برای شما فعال خواهد شد!
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی همه کاربران به متن مطالب خریداری نمایند!