The effects of prolonged azathioprine administration on blood cells, lymphocytes and immunoglobulins of Iranian mixed-breed dogs
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
Azathioprine is an immunosuppressive agent that is used in a variety of dermatologic, digestive and hematologic disorders in both humans and small animals.
Aims: The effects of long term Azathioprine administration on complete blood count, rate of CD4 and CD8 lymphocytes, serum immunoglobulins and protein concentrations of mixed-breed dogs were evaluated in this study.
Methods
24 healthy mixed-breed dogs were divided randomly into two equal control and treatment groups. Dogs in the treatment group received the therapeutic dose of Azathioprine for four months, while the dogs in the control group didnt receive this drug. Peripheral blood samples were taken from both two groups before and after the trial to check CBC, CD4 and CD8 lymphocytes and the concentrations of total protein, albumin, serum IgM and IgG.
Results
There was significant decrease in the levels of WBC, RBC, hematocrit and CD4 lymphocyte and double positive CD4/CD8 rates (all p values
Conclusions
Myelotoxicity induced by Azathioprine could be the probable cause of decrements in the rate of WBC and RBC. Decrease in the rate of dpCD4/CD8 might be due to decrement in dpCD4/CD8 progenitor cells and/or decrease in the activation rate of single positive T cells as the result of pharmacological effect of Azathioprine. Disrupted synthesis processes, from genes to proteins through Azathioprine might be the cause of decreases in the level of serum gamma globulins and protein.
Language:
English
Published:
Iranian Journal of Veterinary Medicine, Volume:11 Issue: 4, Autumn 2017
Pages:
361 to 377
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