Design and fabrication of electrochemical biosensor based on β-CD-Graphene nanocomposite for specific adsorption of curcumin, chlorpromazine and clomipramine

A novel nanocomposite based on graphen oxide and beta cyclodextrin molecules was constructed and used for electrochemical detection of curcumin, chlorpromazine and clomipramine. The obtained beta cyclodextrin- graphen nanocomposite was characterized by Fourier Transform infrared (FTIR) spectroscopy, high resolution transmission electron microscopy (HRTEM) and electrochemical impedance spectroscopy (EIS). FTIR results showed that beta cyclodextrin molecules are attached to graphene sheets with hydrogen bonding. HRTEM images showed single layers of graphene oxide nanosheets and the homogenous distribution of betacyclodextrin molecules on to the surface of graphen oxide sheets. The fabricated sensor represents good electrochemical response toward oxidation of these drugs via differential pulse voltammetry. For curcumin, chlorpromazine and clomipramine oxidation peak current was recorded at 0.48, 0.61 and 0.31 V.