Levofloxacin Resistance in Blood and Urine Culture Samples in Khalij Fars Hospital of Bushehr

Due to broad spectrum antimicrobial activity of Levofloxacin, it has been used widely around the world. Recently levofloxacin-resistance reports have been published. This study was done to evaluate resistance to levofloxacin in positive urine and blood cultures in Persian Gulf hospital in Bushehr, during 2015-16.
In this cross- sectional study all positive urine and blood cultures were enrolled, if the amount of the isolated pathogen colony counts were more than 105. Culture samples were divided into 3 groups including sensitive, intermediate and resistant; based on bacterial growth around discs. SPSS version 18.0 was used as the statistical analysis program, and a p-value of less than 0.05 was considered statistically significant.
Cultures belonged to 150 patients including 61 (%40.7) male and 89 (%59.3) female subjects with mean age of 42.98 ± 29.25 years were studied. Culture samples were consisted of urine (% 50.7) and blood cultures (% 49.3). E.coli was the most common pathogen (% 46) and Klebsiella (% 16.7) was the second pathogen in all cultures. Regarding sensitivity to levofloxacin, 119 (% 79.3) samples were sensitive, 22 (% 14.7) culture had intermediate sensitivity and 9 (%6) samples were resistant to levofloxacin. The only resistant pathogen was E.coli.
This study showed that Levofloxacin has good activity
against many pathogens except for E.coli infections that showed some resistance. However , it can still be a good choice in treatment of most infections.