Anti-coagulation therapy following coronary endarterectomy in patient with coronary artery bypass graft
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
Since there is a lack of research on postoperative anticoagulation protocol in patients undergoing coronary artery bypass graft (CABG) / coronary endarterectomy (CE), we recommend a new protocol for anticoagulation in these patients.Methods
In this double-blind randomized clinical trial study, 52 patients undergoing CABG / CE entered the study and were divided into two groups. In group 1, the patients were given warfarin(international normalized ratio (INR) between 2-3) together with 80 mg aspirin daily for 3 months. In group 2, the patients were given 75 mg plavix daily together with 80 mg aspirin daily for 3 months. We evaluated patients with electrocardiography, echocardiography and checking ceratin phosphokinase MB and troponin I in the several stages. The data were analysed SPSS Version18 software.Results
There was no significant difference between pre and post-operative Ejection fraction in patients with plavix (P=0.21) and warfarin (P=0.316) regimen. However, wall mrotion score was significantly better in clopidogrel aspirin patients in late (3 months) post operation (pConclusions
Since warfarin has serious hemorrhagic complications and requires closed monitoring of serum drug activity by serial INR checking, it is recommended that clopidogrel aspirin can be the preferred alternative anticoagulation therapy in CABG / CE patients.Keywords:
Language:
English
Published:
Caspian Journal of Internal Medicine, Volume:9 Issue: 1, Winter 2018
Pages:
27 to 31
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