Relationship Between SOX17 Gene Expression and Prognosis in Acute Myeloid Leukemia

Acute Myeloid Leukemia (AML) is a group of heterogeneous malignancies caused by defects in differentiation of hematopoietic cells. SRY-box containing gene 17(SOX17) is a transcription factor which plays an important role in several biological processes, including cardiogenesis, angiogenesis, and lymphopoiesis. Aberrant expression of SOX17 has been detected in solid tumors. This study was performed to investigate the alternations of SOX17 expression in AML patients.
This case-control study included 54 AML patients who were referred to Molecular Pathology Cancer Research Center of Ghaem Hospital in North East of Iran from October 2011 to May 2016. Patients were classified according to French-American-British (FAB) and World Health Organization (WHO) criteria. RNA was extracted from peripheral blood. SOX17 gene expression was evaluated by real-time quantitative polymerase chain reaction (RQ-PCR).
Over expression of SOX17 was observed in 34 (62.96%) AML patients. No relation was noticed between SOX17 expression and patient survival (p=0.493). In addition, no correlation among patient survival, Sex(p=0.322),hemoglobin(p=0.866) and white blood cell (WBC) (p=0.103).
Based on these results, SOX17 did not have any important role in AML pathogenesis. Thus, it can’t be used as a diagnostic and prognostic factor. However, more studies are required to fully elucidate the role of SOX17 in AML.