ASSOCIATION OF VITAMIN D STATUS AND BSMI POLYMORPHISM IN VITAMIN D RECEPTOR GENE WITH HASHIMOTO DISEASE IN URMIA

The hashimoto thyroiditis as a common autoimmune thyroid disease have a multifactorial etiology. Vitamin D status and vitamin D receptor gene BsmI polymorphism are involved in hashimoto developing. The aim of this research was to study the association between 25hydroxy vitamin D serum levels and BsmI polymorphism with hashimoto.
We conducted a case-control study of 105 adults with hashimoto thyroiditis and 105 matched healthy controls. BsmI polymorphism was investigated by PCR-RFLP. Moreover, after matching two groups for vitamin D intakes from diet and sun exposure habits, serum levels of 25-hydroxyvitamin D as vitamin D status were measured by electrochemiluminescence immunoassay. Data were analyzed with chi-square test, odds ratio, ANOVA, Mann-Whitney U test and independent t-test.
Vitamin D deficiency (≤20ng/ml) was associated with higher susceptibility to hashimoto compared with vitamin D sufficiency (≥30ng/ml) (P = 0.02; adjusted OR = 2.74 CI 95%, 1.2-6.25). BsmI-"GG" genotype was higher in hashimoto group (P = 0.01). BsmI polymorphisms were not effective in vitamin D status (P> 0.05).
Our results revealed that vitamin D status and BsmI polymorphisms are involved in susceptibility to hashimoto disease. Further investigations of the relationship between VDR gene polymorphisms with hashimoto and vitamin D status are needed.