Association between inflammatory factor, lipid peroxidation and total-antioxidant in non-diabetic patients of coronary artery disease

The oxidative stress and inflammation are cooperative events involved in atherosclerosis development. In the present study, we assessed the association ofmalondialdehyde (MDA), antioxidant markers, high sensitive C-reactive protein (HS-CRP)and lipid status parameters in non-diabetic patients with coronary artery disease (CAD) orvessel heart disease (VHD). Significant risk factors such as diabetes were excluded from thestudy.
Oxidative stress parameters for example MDA, antioxidant markers including:erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), inflammation marker and serum lipid status parameters were measured in 120 subjects including 60 CAD patients (non-diabetic) with angiographically diagnosed CADand 60 CAD-free subjects as a control group, also diabetic patients with malignancy, renal andliver disease, and other disease were excluded from the study.
The serum MDA and HS-CRP levels were increased significantly as compared to thecontrols. However, erythrocyte SOD, GPX activities and TAC level were reduced significantly in patients (non-diabetic) (P The association between oxidative stress parameters, antioxidant markers, theinflammation index and lipid status parameters suggest their involvement in atherosclerosis development that may lead to CAD progression.