Protective Effect of Cinnamon Extract on Ibuprofen-Induced Hepatotoxicity in Rats

Ibuprofen is a nonsteroidal anti-inflammatory medication of drugs that is used for relieving pain. However, this drug has proven effects, such as the production of free radicals and interfering with cellular events. Thus, it is necessary to find suitable antioxidants to reduce the side effects of this drug. In this study the antioxidant effects of cinnamon extract on the inhibition induced hepatoxicity of ibuprofen has been investigated.
48 rats in six groups, S group received saline solution, C200 group received cinnamon extract 200mg per kg body weight (200mg/kg b.w), I group ibuprofen 400mg/kg b.w, IC50 group ibuprofen together with cinnamon extract 50mg/kg b.w, IC100 group ibuprofen together with cinnamon extract 100mg/kg b.w, IC200 group ibuprofen together with cinnamon extract 200mg/kg b.w intraperitoneally. The activity of liver enzymes were measured in the end of the experimental period. Liver tissue sample was prepared and after staining with hematoxylin-eosin, was studied.
The activity of Pyruvate transaminase, oxaloacetate transaminase and alkaline phosphatase in I group in comparison with S group were significantly increased. The activity of these enzymes in IC50, IC100 and IC200 groups in comparison with I group were significantly decreased nearly in a dose dependent manner. Examining the liver tissue indicate tissue damage caused by ibuprofen, and cinnamon consumption was reduced tissue destruction.
Cinnamon extract has antioxidant properties and reduces the ibuprofen induced hepatoxicity.