The Effect of Smoking on Mast Cells Density and Angiogenesis in Chronic Periodontitis
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background And Objective
Gingival bleeding reduction in smokers has been associated with decreased blood vessel density. The mechanism of suppressive effect of cigarette smoking on blood vessel density is not precisely defined. The aim of this study was to evaluate the impact of smoking on angiogenesis by assessing mast cells density and VEGF expression in chronic periodontitis.Materials and Methods
52 paraffin embedded block of gingiva tissues with periodontitis obtained from 30 nonsmokers and 22 smokers undergoing flap surgery were examined immunohistochemically for VEGF expression. Mast cell counts was completed on toluidine blue stained slides. Exposure to cigarette smoking was calculated by the number of packs × year. Patients were classified into 4 groups based on the number of smoked cigarettes. The correlation between VEGF expression and mast cell counts was evaluated and compared in nonsmokers and smokers.Results
The mean number of mast cells (p=0.004) and average value of VEGF expression (p = 0.000) in nonsmokers was significantly higher than smokers. No correlation was noted between VEGF expression / mast cell counts and number of smoked cigarettes in four groups of smokers (p=0.29,0.12 , 0.20 and 0.11, respectively).Conclusion
Mast cells and VEGF expression may account for suppressive effect of cigarette smoking on blood vessels in periodontitis. Keywords:
Language:
English
Published:
Iranian Journal Of Pathology, Volume:12 Issue: 4, Autumn 2017
Pages:
384 to 391
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