Comparison of the Effect of Artemisia Sieberi Essential Oil and Albendazole Drug on Protoscolices of Hydatid Cyst under in Vitro Conditions
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background And Objective
Hydatidosis is a major zoonotic disease, and the best treatment for this disease is surgery. So far, many chemical protoscolex killers have been used to prevent protoscolices leakage during surgery, but it is necessary to consider the adverse effects of chemicals and the use of medicinal herbs. Considering the antiparasitic properties of Artemisia sieberi, this study was conducted to evaluate and compare the effect of Artemisia sieberi essential oil and albendazole drug on protoscolices of hydatid cyst under in vitro conditions.
Methods
In this laboratory study, essential oils were prepared from aerial parts of the plant. Gas chromatography–mass spectrometry was performed to determine its components. Protoscolices were extracted from the livers infected with hydatid cyst and were exposed to Artemisia sieberi (2.5, 5 and 10 μg/ml) for 10, 30, 60 and 120 minutes. The viability of protoscolices was measured by eosin staining. Albendazole was used as a standard drug.
Results
31.5% alpha-Thujone was identified as the main composition pf essential oil. The amount of essential oil protoscolices at the concentration of 2.5 μg / ml in 10, 30, 60 and 120 minutes was 51.8, 71.5, 82.8 and 99.3%, respectively. Albendazole showed lower toxic effect with similar dose at similar intervals, but both treatments showed a significant effect (p
Conclusion
The results of the study showed that Artemisia sieberi essential oil has an acceptable scolicidal effect compared to albendazole and can be used as a scolicidal agent.
Language:
Persian
Published:
Journal of Babol University of Medical Sciences, Volume:19 Issue: 12, 2017
Pages:
63 to 68
magiran.com/p1781680  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!