Assessment and Simulation of airflow pattern and particle with CFD method in a pharmaceutical industry

clean room is an environment fully enclosed where parameters such as airborne particles under control and is requirement in the pharmaceutical industries to produce quality products. The aim of this study was to assessment and simulation of airflow and particle of clean room by CFD method in a pharmaceutical industry.
This study used an experimental study that was conducted at 2015 in the pharmaceutical industry. The methodology used in this study was to evaluate the level and number of particles in the clean room according to the standard ISO 14644 – 3. Also, air flow and particle in cleanroom with cleanness of class C was simulated with Computational Fluid Dynamics.
The results showed that the path of particle movement and distribution of particles in the clean room completely depend on the shape of the flow and the pattern of air flow in the clean room. Furthermore, the results of the simulation showed that the particles in the clean room wall return particle removal efficiency of 70% at 0.5 and 5 microns.
There is equipment and a tool in a clean room effects on the airflow pattern. The results of simulation showed that the pattern of dispersion, air flow in the clean room is the most affected by the removal of particles.