Effect of Hydroalcoholic Extract of Wheat Sprout On Histology and Histometry Structure of Rat's Prostate Exposed to Lead

Toxic elements can seriously affect prostate gland. One of the toxic material with a high prevalence is lead. On the other hand, medicinal herbs such as wheat sprout can be used for reducing the heavy metal toxicities. This study investigated the effects of wheat sprout extract on histological and histometrical structure of prostate gland in rats exposed to lead acetate.
Thirty rats were divided randomly into six groups: G1 (control group) received 1 ml/kg/day of normal saline, G2 received 20 mg/kg/day of lead acetate, G3 and G4 received 100 mg/kg/day and 200 mg/kg/day of wheat sprout extract respectively, G5 and G6 received 100 mg/kg/day and 200 mg/kg/day of wheat sprout extract respectively with 20 mg/kg/day of lead acetate. After 35 days, rats were sacrificed and blood and prostate tissue samples were collected for histomorphological and histochemical studies.
Results showed a significant decrease in epithelial height of secretory units (P= 0.02) and percentage of parenchyma to stroma (P= 0.036) in lead group, compared to that in control group. On the contrary, a significant increase was seen in epithelial height in group receiving wheat sprout extract (200 mg/kg/day), compared to control group (P= 0.033). Serum testosterone and antioxidant activity (AOA) showed a significant decrease in lead group, compared to control group (P Wheat Sprout extract is effective in improving the tissue structure of the prostate gland in rats exposed to lead acetate.