The Effects of Thymoquinone Against Morphine‐induced Damages on Male Mice Liver
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
Morphine is a pain medication .It is mostly processed in liver and reasons disturbing effects. It can increase the production of free radicals. Thymoquinone is a phytochemical compound found in the plant Nigella sativa. It has diverse pharmacological properties such as antioxidant and anticancer. This study was intended to assess the effects of thymoquinone against morphine damages on the liver of mice.Methods
In this study, various doses of thymoquinone (4.5, 9,and 18 mg/kg) and thymoquinone plus morphine wasadministered (once a day) intraperitoneally to 48 male mice for 20 consequent days. These mice were randomly assigned to eight groups (n = 6). Aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, serum nitric oxide (NO) levels, liver weight, and histology have been studied.
Results
The results indicated that morphine administration signifcantly increased the mean diameter of central hepatic vein and hepatocyte, blood serum NO level, liver enzymes level, and decreased liver weight compared to saline group (P Conclusions
It seems that antioxidant effect of thymoquinone could protect damage of liver parameters against morphine toxicity.Keywords:
Liver , mice , morphine , thymoquinone
Language:
English
Published:
International Journal of Preventive Medicine, Volume:9 Issue: 1, Jan 2018
Page:
5
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