Effects of Different Exercise Training on Vascular Endothelial Function- Meta Analysis Iranian and International Studies

The aim of this peper was meta-analysis of studies on the effectiveness of different exercise training on vascular endothelial function. To assessment studies in the field of vascular endothelial function search was done in databases; PubMed, scienceDirect, Scopus, Web of science, SID, Magiran and google Scholar with specified keywords among articles that were published in the years 1986 to 2016 both in Persian and English. After initial screening, full text search and critical appraisal, studies which pass the inclusion criteria were analyzed. Among imported article, 14 study which included 17 trials with meta-analysis inclusion criteria were analyzed. The results of the meta-analysis of studies showed that exercise can improve flow mediated dilation in healthy subjects (SMD=0.75, 95% CI 0.49–1.00, P=0.001) and patients with coronary artery disease (SMD=0.47, 95% CI 0.29–0.65, P=0.001). Although the effect size obtained for various exercise training are different, but considering the low number of studies, we cannot make an absolute statement about the superiority of one method of training. The exercise can be effective in improving endothelial function, although still high-quality research studies with sufficient sample size is needed.