Toxic Effect of Cerium Oxide Nanoparticles on Mice Testis

Background and Cerium oxide nanoparticles (CNPs) are widely used as a catalyst in industry and as an antioxidant in applied nanomedicine. The biological effect of CNPs exposure on testis tissue is not known. The objective of this study was to evaluate the effect of CNPs on testis in mice model.
In this experimental study, CNPs were administered intraperitoneally at 5 mg/kg dose for 7 consecutive days. Testicular toxicity was evaluated by histopathological, biochemical, and immunohistochemical assays.
According to the findings CNPs significantly induced oxidative stress in testis (P Such observations suggest that CNPs at 5 mg/kg dose with pro-oxidative stress effect can lead to testicular toxicity. Also, this study confirmed that CNPs could pass through the blood-testis barrier.