Synthesis and characterization of MWCNT/PEG@CD nanocomposite as carrier for sustained delivery of Acyclovir

The synthesis of multiwalled carbon nanotubes/poly ethylene glycol and β-cyclodextrin inclusion complex (MWCNT/PEG@ β-CD) as nanoplatform for the loading and delivery of Acyclovir (Acy) drugs is described here. The functionalized multi wall carbon nanotubes (e.g. MWCNT-COOH, MWCNT/ PEG and MWCNT/PEG@CD) have been characterized by FTIR and HNMR spectroscopy, electron microscopy (SEM) and differential scanning calorimetry (DSC) to achieve insights on structure, morphology and chemical composition. In this work, the drug binding abilities of MWCNT/PEG@ β-CD nanocomplex towards the Acyclovir (Acy) were proved by UV–vis and DSC experiments. The release studies showed a sustained delivery of Acy without initial burst effect confirming a strong interaction of drug with the nanoplatform sites. Finally, it was approved that the nanocarrier obtained from MWCNT/ PEG@CD is able to connect and sustained release of Acy in physiology condition. In agreement with these finding, MWCNT/PEG@CDs hybrid can be proposed as a biocompatible and biodegradation nanotube for loading a variety kind of drug.