The effect of a endurance training period with cellular Anti-aging purpose on telomerase enzyme content in cardiac tissue and peripheral blood lymphocytes in rats

The purpose of present study was the effect of a endurance training period with cellular Anti-aging purpose on telomerase enzyme content in cardiac tissue and peripheral blood lymphocytes in male rats. For this purpose, rats provided from Pasteur institude of Iran were randomly divided in two group, control (n=8) and exercised groupe (n=8). Two week use for environmental adaptation and biological rhythm (first week) and treadmill familiarity (second week). Then the major protocol of this study began after first two week that include a session endurance exercise per day, five day/week. The intensity of exercise was moderate that exercise group do it for 16 weeks while control group was sedentary in this period. Durig first eight weeks the speed of running on treadmill increased from 15 m/min to 25 m/min and time from 15 min to 25 min progressively but this intensity of exercise fixed during second eight week. One day after end of protocol in fasing situation samoles were collected. The results showed the moderate indurance training significant increased in telomerase content in cardiac tissue (p= 0/004) and peripheral blood lymplocytes (p= 0/004). In summary, the results suggested that the moderate (60-65 % vo2max) and regular physical activity indused activation in telomerase and telomere length stability and exercise and physical activity by telomerase activation in body tissue could increased cellular viability and genomic stability and finally have anti-aging effect.