Preparation of polyurethane nanobers containing cefixime trihydrate: in vitro release kinetic studies

In this study, polyurethane nanofibers were prepared by electrospinning process. An Antibiotic drug, Cefixime trihydrate, was loaded on polyurethane nanofibers. The physical condition and interaction of drug within these nanofibers were studied by FT-IR and SEM. In vitro release studies showed a burst release at the initial stage followed by a sustained release of Cefixime from this system up to 70 h. This burst release can be favorable to reduce the associated surgical site infections, since most of the bacteria are introduced to the surgical site at the time of surgery or in the immediate after the surgery, zero order, first order, Higuchi, Korsmeyere - Peppas equation were utilized to characterize the system.