The Modulatory Effects of Vitamin D on the Expression of IL-12 and TGF-β in the Spinal Cord and Serum of Mice with Experimental Autoimmune Encephalomyelitis
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background & objective The immunoregulatory effects of transforming growth factor (TGF)-βand interleukin-12 (IL-12) and immunomodulatory actions of vitamin D (VD) were reported in several studies. This study aims to evaluate VD effects on IL-12 and TGF-β expression in experimental autoimmune encephalomyelitis (EAE).
Methods
EAE was induced in three groups of C57BL/6 mice by immunization with MOG and administered intra-peritoneally 200 ngVD, PBS or olive oil (OO) from day to . One group was also considered as healthy control group. At day 31, cytokines expression in the spinal cord and their serum levels were determined using real time-PCR and ELISA, respectively.Results
IL-12 gene expression and its serum levels in PBS-injected- or OO-administrated EAE groups were significantly higher than healthy group. IL-12 gene expression in EAE group treated with VD was significantly decreased compared to PBS-injected- or OO-administrated EAE groups (PConclusion
VD modulates the expression of IL-12 and TGF-β in spinal cord and serum of EAE mice. Keywords:
Experimental Autoimmune , Encephalomyelitis , Vitamin D , IL , 12 , TGF , ?
Language:
English
Published:
Iranian Journal Of Pathology, Volume:13 Issue: 1, Winter 2018
Pages:
10 to 22
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