Antimicrobial Effect of Staphyloxanthin on pathogenic bacteria

Expanded and on limited consumption of Antibiotics to cure Staphylococcus aureus has been resulted with appearance of different kinds of staphylococcus aureus which on resistant of antibiotics ( MRSA ). Objective of this study is to research antibiotics quality of staphyloxanthin ( golden pigment of staphylococcus aureus ) on different kinds of pathogen bacteria and also observing staphyloxanthin genes ( crtM ) in staphylococcus aureus extracted from clinical sources.
Totaly 170 sampels of staphylococcus aureus collected from clinical sources ( parts of skin, blood, urine and nose ). Having all these samples and hands- staphyloxanthin content of 20 samples with golden colonies separated and their anti microbial property 3 in testing bacteria, Escherichia coli, Yersinia enterocolitia, klebsiella, were studied. Furthermore, after extraction of DNA in order to observe bands of staphyloxanthin gene PCR operation was done.
staphyloxanthin did not have anti-microbial effect on Escherichia coli, Yersinia enterocolitica, klebsiella bacteria. In performing PCR existence of staphyloxanthin gene band in 95% of genes were confirmed.
Result of this study, which is done for the first time in iran, existence of staphyloxanthin gene ( crtM ) in all of the bacteria is proved . It seems that staphyloxanthin does not have any interference of pathogen bacteria in human beings. But, in fact, staphyloxanthin has an important role in keeping bacteria alive in the host during fighting against immunity system.