Investigation of the Antimicrobial and Interaction of the Aqueous and Ethanolic Extracts of Cordia myxa on some Pathogenic Microorganisms in vitro
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Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background And Objective
Cordia myxa belongs to Boraginaceae family and is considered a medicinal plant in Iran. In traditional medicine, each part of Cordia myxa for the treatment of various infections and diseases is used. The purpose of the present study was to investigate the antimicrobial activity of Cordia myxa leaves extracts against some pathogenic microorganisms “in vitro”.
Materials And Methods
In this experimental study, the antimicrobial effects and interaction of the aqueous and ethanolic extracts of Cordia myxa leaves on Staphylococcus aureus, Bacillus cereus, Listeria innocua, Escherichia coli, Pseudomonas aeruginosa and Candida albicans were evaluated by different methods including disk diffusion, minimum inhibitory concentration (broth microdilution), minimum bactericidal/fungicidal concentration and fractional inhibitory concentration.
Results
The minimum inhibitory concentration (MIC) of the aqueous extract of Cordia myxa varied from 128 mg/ml to 256 mg/ml, while the MIC for the ethanolic extract of Cordia myxa ranged from 64 mg/ml to 256 mg/ml. Pseudomonas aeruginosa was the most resistant bacterium to the aqueous and ethanolic Cordia myxa leaves extracts. The minimum bactericidal/fungicidal concentration (MBC/MFC) of the aqueous extract was 128, 256, 256, 512, 512 and 128 mg/ml for Staphylococcus aureus, Bacillus cereus, Listeria innocua, Escherichia coli, Pseudomonas aeruginosa and Candida albicans, respectively. Moreover, the MBC/MFC of the ethanolic one was equal to 64, 128, 256, 256, 512 and 128 mg/ml for the same microorganism, respectively.
Conclusion
According to the results of this study, aqueous and ethanolic Cordia myxa leaves extracts considerably inhibited the growth of pathogenic microorganisms. However, clinical applications of these extracts need further investigations.
Language:
Persian
Published:
Iranian Journal of Infectious Diseases, Volume:22 Issue: 79, 2018
Pages:
41 to 50
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