Comparative study of antinociceptive effects of magnesium sulfate and lidocaine intra and postoperative surgery in animal model

The aim of the present study was to evaluate the antinociceptive efficacy of three lumbosacral analgesic protocols for elective tail ducking surgery in dogs received acepromazine premedication.
15 dogs were randomly divided in 3 groups. Evaluated treatments were lidocaine (4mg/kg) alone (group1), magnesium sulphate (2.5 mg/kg ) in combination with lidocaine (4 mg/kg) (group2) and magnesium sulphate (2.5 mg/kg) alone ( group3) that were injected in the epidural space. Analgesia was assessed before surgical procedure using Von Frey device. Analgesia was evaluated during and after surgery, too.
The decrease of pain was significant in three treated groups during and after surgery (P Based on the present results it is concluded that magnesium sulfate injected into the lumbosacral epidural space of dogs causes to an antinociceptive effect in A δ and C- fibers without any motor functional deficits. Additionally, magnesium sulfate- lidocaine combination produce suitable postoperative analgesia.