Investigating the expression of CCAT2 gene as a new molecular marker in breast tumors

lnc-CCAT2 is a non-protein coding RNA, which is highly expressed in tissues and cancer cell types. Due to the increasing incidence of breast tumors in recent years, in this research, the qualification of CCAT2 gene expression is assessed as a potential molecular marker in the diagnosis and treatment of breast tumors.
Material & Totally, 35 breast tumor specimens and 35 non-tumoral ones related to the tumor margins were studied using quantitative real-time PCR method. Gene β2m was used as the internal control. Obtained results were statistically analyzed Using the SPSS and sigmaplot software.
The results showed that CCAT2 gene expression, significantly increased in breast tumor samples compared to marginal non-tumor specimens. (P This results showed that CCAT2 gene can be applied as a diagnostic marker for the identification and diagnosis of breast tumor tissues and non-tumor types. Therefore, it can be used alongside other conventional Diagnostic Laboratorial methods. More studies are underway on the biomarking potentiality of this gene.