Investigating the Protective effect of hesperetin in high fat diet-induced fatty liver disease in rat
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background and Objective
Fatty liver disease as the most common type of liver disease, is usually accompanied with obesity, hyperlipidemia, and diabetes mellitus Type 2. The aim of the present study was to evaluate the protective effects of Hesperetin on high fat diet-induced hepatic steatosis.
Material &
Methods
Thirty two Wistar male rats were treated in 4 experimental groups including: control group, high fat diet group, high fat diet plus Clofibrate as positive control, and high fat diet plus Hesperetin powder (5 mg/kg), at a period of 6 weeks. At the end of experiment, the groups were compared considering serum lipid profile, serum biomarkers of liver tissue injury and antioxidant activity of liver, using ANOVA test. Histopathology of liver was carried out for confirming the biochemical findings.
Results
There were significant changes as shown by the results. In high fat diet group, hypertriglyceridemia, hypercholesterolemia, significant increased activities of hepatocellular enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase) in plasma, significant decline in antioxidants (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase), and elevated lipid peroxidation indices in liver were seen (p
Conclusion
The results showed that Hesperetin exerts protective effects against hepatic steatosis in rats fed with high fat diet through its antioxidant actions
Language:
Persian
Published:
Journal of Advanced Biomedical Sciences, Volume:7 Issue: 4, 2018
Pages:
498 to 510
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