Effect of Vitamin D Supplementation on Weight Loss, Glycemic Indices, and Lipid Profile in Obese and Overweight Women: A Clinical Trial Study

Vitamin D deficiency is considered as a public health problem throughout the world. The aim of this study was to evaluate the effect of vitamin D on weight loss, high-sensitivity C-reactive protein (hs_CRP), and insulin resistance in obese and overweight women.
This double blind clinical trial was done on 53 overweight and obese women who divided into two groups. The intervention group received vitamin D supplements with doze of 50000 IU per week for 6 weeks and another received placebo. The anthropometric factors and biochemical markers were measured before and after intervention. Independent samples t and paired samples t test were used to compare the mean between and within groups, respectively.
Findings: Serum vitamin D increased significantly compared to control group (P 0.050 for all).
The evidence of this study suggests that supplementation of vitamin D in obese and overweight women did not confirm the effect of vitamin D supplementation on anthropometrics, body mass index (BMI), hs_CRP, and insulin resistance.