Evaluation of the Effect of Malva Parviflora Hydro-alcoholic Extract on Pain in Male Rat
Abstract:
Background And Objective
Due to the low side effects of active ingredients of medicinal plants, they are considered appropriate alternatives to synthetic drugs. Malva periflora has anti-inflammation effects in folk and herbal medicine. In this study the anti-nociceptive and anti-inflammatory effects of Malva parviflora were investigated.
Subjects and
Methods
In this study seventy two Wister male rats were used: negative control group that received no treatment, sham group received normal saline (1ml), Test groups received respectively 100, 200, 400, 600 or 800 mg/Kg extract for 10 days by gavages. Positive control group received 600 mg/Kg extract with 300mg/Kg Aspirin intraperitoneally; Group received 600mg/Kg extract and naloxone (10 mg/Kg) intraperitoneally. Pain was tested by formalin test by subcutaneous administration of 50 µl formalin 2.5% in hindpow plantar.
Results
Malva extract had a dose-dependent anti-nociceptive effect on both acute and chronic pains induced by the formalin injection (P
Conclusion
Malva parviflora extract has flavonoid and anti-inflammatory compounds. Yet prostaglandins release could probably be decreased by inhibiting cyclooxygenase activity.So it reduces pain in chronic phase thanks to its anti-inflammatory properties.
Article Type:
Research/Original Article
Language:
Persian
Published:
Jundishapur Scientific Medical Journal, Volume:17 Issue:1, 2018
Pages:
95 - 105
magiran.com/p1810540  
روش‌های دسترسی به متن این مطلب
اشتراک شخصی
در سایت عضو شوید و هزینه اشتراک یک‌ساله سایت به مبلغ 300,000ريال را پرداخت کنید. همزمان با برقراری دوره اشتراک بسته دانلود 100 مطلب نیز برای شما فعال خواهد شد!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی همه کاربران به متن مطالب خریداری نمایند!