The Effect of Intraperitoneal Injection of Ferulae Angulata Hydroalcoholic Extract on Pentylenetetrazole-Induced Epilepsy in Male Mice

Seizure is one of the most common symptoms of epilepsy caused by abnormal electrical activity of neurons; Because of the side effects of chemical drugs the use of herbal medicines can be a good alternative to seizure control. In this study the effectiveness of Ferulago angulata (Schlecht, Boisss) hydroalcoholic extract was investigated in pentylenetetrazole (PTZ)-induced seizure in male mice.
Subjects and In this experimental study, 48 male mice weighing 25-30g were divided into 6 groups': saline; positive control group (received diazepam as standard an anticonvulsant drug at 1 mg/Kg) and 4 experimental groups (100, 200, 400, 800mg/Kg of extract) respectively. All the animal groups received intraperitoneally pentylenetrazole (85 mg/Kg), 30 minutes after appropriate treatment protocol.
Injection of Ferulago angulata hydroalcoholic extract delayed the onset of seizure at 400 dose (P In general, intraperitoneal injection of Ferulago hydroalcoholic extract causes delay in attacks in various phases of seizure and it seems the future studies will be necessary to separate its ingredients and understand its mechanism of action.